Year : 2017  |  Volume : 13  |  Issue : 2  |  Page : 50-55

Chronic leg ulcers in patients with sickle cell anemia: Experience with compression therapy in Nigeria

1 Department of Surgery, University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria
2 IAMRAT, College of Medicine, University of Ibadan, Oyo State, Nigeria
3 Federal Medical Centre, Owo, Ondo State, Nigeria
4 Department of Surgery, University College Hospital, Ibadan, Nigeria
5 Sickle Cell Hope Alive Foundation (SCHAF), Ibadan, Oyo State, Nigeria

Correspondence Address:
Dr. Ayodele O Ogunkeyede
Department of Surgery, University of Ilorin Teaching Hospital, Ilorin, Kwara State
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/njps.njps_16_17

Rights and Permissions

Objective/Purpose: A pilot study to assess the efficacy of compression therapy on the healing rate of chronic leg ulcers (CLUs) in patients with sickle cell anemia (SCA) in Nigeria. Materials and Methods: A cohort study of patients with SCA and CLU complication was conducted using simple random sampling method to enroll patients from communities in Ibadan, Oyo State, Nigeria. A total of 18 patients with SCA having a total of 25 chronic leg ulcers and ankle brachial pressure index >1 were treated with a high compression bandage of four layers on a weekly basis after wound assessment for a period of 3 months. Wilcoxon signed-rank test was used to compare wound area at pre- and postintervention. Results: The enrolled patients with SCA were in the age range of 19–44 years, and mean ± SD was 28.8 ± 6.5 years. The initial median ulcer size was 38.4 cm2 (range 0.5–416 cm2); 21 leg ulcers (84%) were >10 cm2 in size at the beginning of the study. These leg ulcers had been present for a median age of 7 years (range 1–22 years). The compression therapy technique achieved >50% healing rate in 16 legs (64%) with an initial ulcer size of 0.5–312 cm2. Four leg ulcers (16%) were completely healed during the study. The postintervention median ulcer size was 18.6 cm2 in all the 25 leg ulcers studied (P < 0.001). Conclusion: Compression wound therapy promotes a positive healing rate of the CLUs in patients with SCA in Nigeria.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded154    
    Comments [Add]    
    Cited by others 1    

Recommend this journal